ABSTRACT
Background and aim: periodontal diseases are of the most common problems in oral cavity which frequently require surgery. Some of the patients because of their impossibility to take conventional analgesics due to systemic problems and post-surgical pain and also intolerance toward periodontal pack for one week, refuse surgery. Therefore, it seems advantage use to perform surgery free from such complications. The aim of this study was to investigate the effects of Benzydamine HCL for post-surgical periodontal patients
Materials and Methods: for thirty patients with similar periodontal problems on contralateral sides of the mouth full thickness flap was performed at an interval of SLY weeks. No periodontal pack was used following surgery. Patients were given Benzydamine HCL or a placebo randomly and asked to rinse mouth for a 7-day period every four hours. During this period, a questionnaire on pain was filled by each patient. Plaque and bleeding indices were also evaluated at 0, 1, 3 and 7 days post-surgery. Six weeks later the second surgical procedure was carried out on contralateral part of the mouth and if patients received Benzydamine HCL, now used a placebo and vice versa. Data were analyzed statistically using t-test and variance analysis test
Results: the results from 30 regions which were randomly divided into Benzydamine HCL and placebo groups [n=15] showed that all Benzydamine samples suffered from a mild pain on first day and were without pain from the 2nd to 7th day. However, all placebo samples suffered from a moderate pain on first day and a mild pain from the 2nd to 7th day. Bleeding index, in Benzydamine group, on 3rd and 7th days were 0.73 +/- 0.08 and 0.62 +/- 0.09, respectively which were less than that of placebo group [2.4+/-0.2]. t.test statistical analysis revealed significant difference between two groups [P<0.001]. Plaque index, in Benzydamine group, on 3rd and 7th days were. 1.43 +/- 0.12 and 1.3 +/- 0.18, respectively and those of placebo were 2.06 +/- 0.1 and 2.2 +/- 0.28 that statistically significant differences were found on both days between two groups by t-test [P<0.001]
Conclusion: according to the findings of this research, using Benzydamine HCL mouth rinse 15% post periodontal surgeries can be effective on pain reduction, gingival bleeding and plaque control and may be substituted for periodontal pack and analgesics such as asprine, acetaminophene and Ibuoprophene